Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice

被引：14

作者：

Kaji, Noriyuki ^{[1
]}

Nagakubo, Dai ^{[1
]}

Hashida, Shin-ichi ^{[1
]}

Takahashi, Saya ^{[1
]}

Kuratani, Motoi ^{[1
]}

Hirai, Norihiko ^{[1
]}

Shirai, Mitsuyuki ^{[1
]}

Asai, Fumitoshi ^{[1
]}

机构：

[1] Azabu Univ, Sch Vet Med, Dept Pharmacol, Chuo Ku, Sagamihara, Kanagawa 2525201, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2013年 / 75卷 / 09期

关键词：

blood coagulation time; mouse; obese; rat; visceral fat; FASTING PLASMA-GLUCOSE; CARDIOVASCULAR-DISEASE; WBN/KOB-LEPR(FA) RAT; ADIPOSE-TISSUE; PROFILES; INSULIN; MODEL; RISK;

D O I：

10.1292/jvms.13-0029

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.

引用

页码：1245 / 1248

页数：4

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