Shortened Blood Coagulation Times in Genetically Obese Rats and Diet-Induced Obese Mice

被引：14
|
作者：
Kaji, Noriyuki [1 ]
Nagakubo, Dai [1 ]
Hashida, Shin-ichi [1 ]
Takahashi, Saya [1 ]
Kuratani, Motoi [1 ]
Hirai, Norihiko [1 ]
Shirai, Mitsuyuki [1 ]
Asai, Fumitoshi [1 ]
机构：
[1] Azabu Univ, Sch Vet Med, Dept Pharmacol, Chuo Ku, Sagamihara, Kanagawa 2525201, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2013年 / 75卷 / 09期
关键词：
blood coagulation time; mouse; obese; rat; visceral fat; FASTING PLASMA-GLUCOSE; CARDIOVASCULAR-DISEASE; WBN/KOB-LEPR(FA) RAT; ADIPOSE-TISSUE; PROFILES; INSULIN; MODEL; RISK;
D O I：
10.1292/jvms.13-0029
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of this study was to investigate blood coagulation times in genetically obese rats and diet-induced obese (DIO) mice in order to clarify the relationship between visceral obesity and blood coagulation. WBN/Kob-Lepr(fa) (fa/fa) rats, a genetically obese model, exhibited a significantly shorter activated partial thromboplastin time (aPTT) and prothrombin time (PT) than age-matched Wistar rats. C57BL/6J mice fed a high-fat diet (60%), a DIO model, exhibited significantly shorter aPTT, PT and thrombin time than lean mice fed a standard diet. Higher body weight, visceral fat weight and insulin resistance were also shared by fa/fa rats and DIO mice. These results suggest that visceral obesity is related to accelerated blood coagulation in addition to disrupted metabolism of glucose and lipids.
引用
收藏
页码：1245 / 1248
页数：4
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