Synthesis of 2′,3′-dideoxy-3′-C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent

被引：15

作者：

Ichikawa, E

Yamamura, S

Kato, K ^{[1
]}

机构：

[1] Nippon Kayaku Co Ltd, Pharmaceut Grp, Res Labs, Kita Ku, Tokyo 115, Japan

[2] Keio Univ, Fac Sci & Technol, Dept Chem, Yokohama, Kanagawa 223, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期

关键词：

antivirals; nucleosides;

D O I：

10.1016/S0960-894X(99)00142-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-O-Acetyl-2,3-dideoxy-3-C-(hydroxymethy)-4-thiofuranose derivative was synthesized from (S, S)-1,4-bis(benzyloxy)-2,3-epoxybutane derived from (+)-diethyl L-tartrate and the enantiomerically pure (E)-5-(2-bromovinyl)- 1-[2', 3'-dideoxy-3'-C-(hydroxymethyl)-beta-D-4'-thiopentofuranosyl] uracil 4 was obtained via coupling of silylated uracil followed by palladium-mediated coupling of methyl acrylate. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1113 / 1114

页数：2

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