Synthesis of 2′,3′-dideoxy-3′-C-(hydroxymethyl)-4′-thiopentofuranosyl nucleosides as potential antiviral agent

被引：15
|
作者：
Ichikawa, E
Yamamura, S
Kato, K [1 ]
机构：
[1] Nippon Kayaku Co Ltd, Pharmaceut Grp, Res Labs, Kita Ku, Tokyo 115, Japan
[2] Keio Univ, Fac Sci & Technol, Dept Chem, Yokohama, Kanagawa 223, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 08期
关键词：
antivirals; nucleosides;
D O I：
10.1016/S0960-894X(99)00142-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2-O-Acetyl-2,3-dideoxy-3-C-(hydroxymethy)-4-thiofuranose derivative was synthesized from (S, S)-1,4-bis(benzyloxy)-2,3-epoxybutane derived from (+)-diethyl L-tartrate and the enantiomerically pure (E)-5-(2-bromovinyl)- 1-[2', 3'-dideoxy-3'-C-(hydroxymethyl)-beta-D-4'-thiopentofuranosyl] uracil 4 was obtained via coupling of silylated uracil followed by palladium-mediated coupling of methyl acrylate. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1113 / 1114
页数：2
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