MicroRNAs: Target Recognition and Regulatory Functions

被引：16039
|
作者：
Bartel, David P. [1 ,2 ,3 ]
机构：
[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
来源：
CELL | 2009年 / 136卷 / 02期
基金：
美国国家卫生研究院;
关键词：
UTR SEQUENCE MOTIF; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNAS; C-ELEGANS; GENE-EXPRESSION; BINDING-SITES; K-BOX; LET-7; ACTIVATION; DIFFERENTIATION;
D O I：
10.1016/j.cell.2009.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are endogenous 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
引用
收藏
页码：215 / 233
页数：19
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