MicroRNAs - targeting and target prediction

被引：96
|
作者：
Saito, Takaya [1 ]
Saetrom, Pal [1 ,2 ]
机构：
[1] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, NO-7489 Trondheim, Norway
[2] Norwegian Univ Sci & Technol, Dept Comp & Informat Sci, NO-7491 Trondheim, Norway
来源：
NEW BIOTECHNOLOGY | 2010年 / 27卷 / 03期
关键词：
MESSENGER-RNAS; BINDING-SITES; IDENTIFICATION; BIOGENESIS; EXPRESSION; REGIONS; DETERMINANTS; SPECIFICITY; MECHANISMS; SEQUENCES;
D O I：
10.1016/j.nbt.2010.02.016
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.
引用
收藏
页码：243 / 249
页数：7
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