Determination of Chloramphenicol in Honey and Royal Jelly by Sample Clean-up with Molecular Imprinted Polymer

被引：0
|
作者：
Sakamoto, Yasuhiro [1 ]
Saito, Koichi [1 ]
Hata, Rikuko [1 ]
Katabami, Shiori [1 ]
Iwasaki, Yusuke [1 ]
Ito, Rie [1 ]
Nakazawa, Hiroyuki [1 ]
机构：
[1] Hoshi Univ, Fac Pharmaceut Sci, Dept Analyt Chem, Shinagawa Ku, Tokyo 1428501, Japan
来源：
BUNSEKI KAGAKU | 2012年 / 61卷 / 05期
关键词：
chloramphenicol; MIP; honey; royal jelly; TRACE ANALYSIS; LIQUID; RESIDUES; THIAMPHENICOL; FLORFENICOL;
D O I：
暂无
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A sample clean-up method that employs a molecular imprinted polymer (MIP) was examined for potential use in the residual analysis of chloramphenicol (CAP) in honey and royal jelly. The clean-up effect of MIP was compared with that of conventional reversed-phase solid-phase extraction (SPE). Measurements for evaluating the clean-up efficiency were conducted by LC/UV, LC/MS or enzymed-linked immunosorbent assay (ELISA). LC/UV measurements of a sample after SPE yielded interference peaks originating from impurities on the chromatograms. The recovery was approximately 80 % for honey and 75 % for royal jelly. LC/MS measurements of a sample cleaned up with MIP showed no interference peaks due to the matrix effect. In addition, ELISA conducted on a sample cleaned up with MIP revealed that MIP suppressed interference by impurities in the antigen-antibody reaction. The developed sample clean-up method with MIP was able to remove impurities in dark honey and royal jelly, and is expected to be useful for the determination of residual CAP in live-stock products.
引用
收藏
页码：383 / 389
页数：7
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