Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease.

被引：0
|
作者：
Pozzi, Samantha [1 ]
Yan, Hua
Vallet, Sonia
Vaghela, Nileshwari
Fulciniti, Mariateresa
Cirstea, Diana
Santo, Loredana
Mukherjee, Siddhartha
Hideshima, Teru
Schirtzinger, Linda [2 ]
Kuhstoss, Stuart [2 ]
Munshi, Nikhil C.
Anderson, Kenneth C.
Scadden, David
Raje, Noopur [1 ]
机构：
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA USA
[2] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
来源：
BLOOD | 2008年 / 112卷 / 11期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：946 / 946
页数：1
相关论文
共 50 条
  • [31] Effects of intermediate doses of glucocorticoids on bone turnover and circulating Dkk-1, MIF, sRANKL and OPG in patients with interstitial lung disease. A three-month longitudinal study
    Calzolari, G.
    Dovio, A.
    Palmas, E.
    Data, V.
    Carignola, R.
    Mercante, L.
    Albera, C.
    Angeli, A.
    BONE, 2009, 45 : S140 - S140
  • [32] Novel In Vivo Model of Multiple Myeloma Bone Disease Using β-Tricalcium Phosphate Artificial Bone Grafts
    Koulnis, Miroslav
    Eda, Homare
    Santo, Loredana
    Siu, Ka Tat
    Ramachandran, Janani
    Panaroni, Cristina
    Tanaka, Takaaki
    Raje, Noopur S.
    BLOOD, 2015, 126 (23)
  • [33] Early Evidence of Anabolic Bone Activity of BHQ880, a Fully Human Anti-DKK1 Neutralizing Antibody: Results of a Phase 2 Study in Previously Untreated Patients with Smoldering Multiple Myeloma At Risk for Progression
    Munshi, Nikhil C.
    Abonour, Rafat
    Beck, Joseph T.
    Bensinger, William
    Facon, Thierry
    Stockerl-Goldstein, Keith
    Baz, Rachid
    Siegel, David S.
    Neben, Kai
    Lonial, Sagar
    Suvannasankha, Attaya
    Bilic, Sanela
    Chica, Sandra
    Mukhopadhyay, Subhendu
    Isaacs, Randi
    Jagannath, Sundar
    BLOOD, 2012, 120 (21)
  • [34] Serum levels of OPG and MIP-1α in untreated multiple myeloma patients.: Correlations with staging, survival and bone disease.
    Papadogiannis, A
    Kyrtsonis, MC
    Vassilakopoulos, TP
    Tzenou, T
    Antoniadis, AG
    Kalpadakis, C
    Sachanas, S
    Dimopoulou, MN
    Siakantaris, MP
    Kokoris, SI
    Dimitriadou, EM
    Angelopoulou, MK
    Plata, E
    Tsaftaridis, P
    Pangalis, G
    BLOOD, 2005, 106 (11) : 350B - 350B
  • [35] Investigating the efficacy of bisphosphonates treatment against multiple myeloma induced bone disease using a computational model
    Ji, Bing
    Yang, Qing
    Genever, Paul G.
    Fagan, Michael J.
    BIO-MEDICAL MATERIALS AND ENGINEERING, 2014, 24 (06) : 3373 - 3378
  • [36] Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone disease
    D'Souza, Sonia
    del Prete, Davide
    Jin, Shunqian
    Sun, Quanhong
    Huston, Alissa J.
    Kostov, Flavia Esteve
    Sammut, Benedicte
    Hong, Chang-Sook
    Anderson, Judith L.
    Patrene, Kenneth D.
    Yu, Shibing
    Velu, Chinavenmeni S.
    Xiao, Guozhi
    Grimes, H. Leighton
    Roodman, G. David
    Galson, Deborah L.
    BLOOD, 2011, 118 (26) : 6871 - 6880
  • [37] Human myeloma cells stimulate TNF related activation-induced cytokine (TRANCE) and downregulate IFN-γ in T lymphocytes:: A possible involvement in multiple myeloma bone disease.
    Giuliani, N
    Bataille, R
    Colla, S
    Matteo, M
    Sabrina, B
    Rosanna, V
    Sala, R
    Barille, S
    Rizzoli, V
    BLOOD, 2001, 98 (11) : 809A - 809A
  • [38] Roundabout 1 (ROBO1)/SLIT2 Is a Novel Signaling Pathway in Multiple Myeloma Promoting Survival and Bone Marrow Niche Interaction
    Bianchi, Giada
    Czarnecki, Peter G.
    Roccaro, Aldo M.
    Sacco, Antonio
    Kawano, Yawara
    Samur, Mehmet K.
    Gulla, Annamaria
    Tai, Yu-Tzu
    Ghobrial, Irene M.
    Carrasco, Ruben D.
    Anderson, Kenneth C.
    BLOOD, 2016, 128 (22)
  • [39] The Novel Role of Checkpoint Inhibitor PD-1H/VISTA in Osteoclast Activation and Multiple Myeloma Bone Disease
    Fu, Jing
    Li, Shirong
    Ma, Huihui
    Yang, Jun
    Brown, Lewis M.
    Pagnotti, Gabriel M.
    Weiss, Stephen J.
    Mapara, Markus Y.
    Lentzsch, Suzanne
    BLOOD, 2021, 138
  • [40] A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    Gunn, William G.
    Conley, Adam
    Deininger, Lisa
    Olson, Scott D.
    Prockop, Darwin J.
    Gregory, Carl A.
    STEM CELLS, 2006, 24 (04) : 986 - 991
12345