Promoting Osteoblastogenesis Using a Novel Dkk-1 Neutralizing Antibody in the Treatment of Multiple Myeloma Related Bone Disease.

被引:0
|
作者
Pozzi, Samantha [1 ]
Yan, Hua
Vallet, Sonia
Vaghela, Nileshwari
Fulciniti, Mariateresa
Cirstea, Diana
Santo, Loredana
Mukherjee, Siddhartha
Hideshima, Teru
Schirtzinger, Linda [2 ]
Kuhstoss, Stuart [2 ]
Munshi, Nikhil C.
Anderson, Kenneth C.
Scadden, David
Raje, Noopur [1 ]
机构
[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med,Dana Farber Canc Inst, Jerome Lipper Multiple Myeloma Ctr, Boston, MA USA
[2] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:946 / 946
页数:1
相关论文
共 50 条
  • [21] International Myeloma Working Group Recommendations for the Treatment of Multiple Myeloma-Related Bone Disease
    Terpos, Evangelos
    Morgan, Gareth
    Dimopoulos, Meletios A.
    Drake, Matthew T.
    Lentzsch, Suzanne
    Raje, Noopur
    Sezer, Orhan
    Garcia-Sanz, Ramon
    Shimizu, Kazuyuki
    Turesson, Ingemar
    Reiman, Tony
    Jurczyszyn, Artur
    Merlini, Giampaolo
    Spencer, Andrew
    Leleu, Xavier
    Cavo, Michele
    Munshi, Nikhil
    Rajkumar, S. Vincent
    Durie, Brian G. M.
    Roodman, G. David
    JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (18) : 2347 - U179
  • [22] Inhibiting Dickkopf-1 (Dkk1) Removes Suppression of Bone Formation and Prevents the Development of Osteolytic Bone Disease in Multiple Myeloma
    Heath, Deborah J.
    Chantry, Andrew D.
    Buckle, Clive H.
    Coulton, Les
    Shaughnessy, John D., Jr.
    Evans, Holly R.
    Snowden, John A.
    Stover, David R.
    Vanderkerken, Karin
    Croucher, Peter I.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2009, 24 (03) : 425 - 436
  • [23] Amlexanox inhibition of TBK1/IKKε Signaling Is a Novel Therapeutic Approach for Multiple Myeloma-Induced Bone Disease.
    Sun, Quanhong
    Zhang, Peng
    Adamik, Juraj
    Marchica, Valentina
    Giuliani, Nicola
    Silbermann, Rebecca
    Roodman, G. David
    Galson, Deborah L.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2017, 32 : S313 - S313
  • [24] Myeloma cell expression of 10 candidate genes for osteolytic bone disease.: Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis
    Haaber, Jacob
    Abildgaard, Niels
    Knudsen, Lene Meldgaard
    Dahl, Inger Marie
    Lodahl, Marianne
    Thomassen, Mads
    Kerndrup, Gitte Birk
    Rasmussen, Thomas
    BRITISH JOURNAL OF HAEMATOLOGY, 2008, 140 (01) : 25 - 35
  • [25] CD26 Is a Novel Target for the Treatment of Tumor Progression and Its Related Osteolytic Bone Disease in Multiple Myeloma
    Nishida, Hiroko
    Madokoro, Hiroko
    Suzuki, Hiroshi
    Hayashi, Mutsumi
    Morimoto, Chikao
    Sakamoto, Michiie
    Yamada, Taketo
    BLOOD, 2015, 126 (23)
  • [26] Treatment of multiple myeloma-related bone disease: recommendations from the Bone Working Group of the International Myeloma Working Group
    Terpos, Evangelos
    Zamagni, Elena
    Lentzsch, Suzanne
    Drake, Matthew T.
    Garcia-Sanz, Ramon
    Abildgaard, Niels
    Ntanasis-Stathopoulos, Ioannis
    Schjesvold, Fredrik
    de la Rubia, Javier
    Kyriakou, Charalampia
    Hillengass, Jens
    Zweegman, Sonja
    Cavo, Michele
    Moreau, Philippe
    San-Miguel, Jesus
    Dimopoulos, Meletios A.
    Munshi, Nikhil
    Durie, Brian G. M.
    Raje, Noopur
    LANCET ONCOLOGY, 2021, 22 (03): : E119 - E130
  • [27] Targeting CCR1 for the treatment of osteolytic bone disease in multiple myeloma
    Vallet, Sonia
    Raje, Noopur
    Fulciniti, Maria Teresa
    Ishitsuka, Kenji
    Hideshima, Teru
    Podar, Klaus
    Pozzi, Samanatha
    Breitkreutz, Iris
    Kiziltepe, Tanyel
    Okawa, Yutaka
    Ikeda, Hiroshi
    Santo, Loredana
    Mukherjee, SIddhartha
    Vaghela, Nileshwari
    Cirstea, Diana
    Boccadoro, Mario
    Anderson, Kenneth C.
    BLOOD, 2007, 110 (11) : 738A - 738A
  • [28] Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    Yaccoby, Shmuel
    Ling, Wen
    Zhan, Fenghuang
    Walker, Ronald
    Barlogie, Bart
    Shaughnessy, John D., Jr.
    BLOOD, 2007, 109 (05) : 2106 - 2111
  • [29] Elotuzumab: a novel anti-CS1 monoclonal antibody for the treatment of multiple myeloma
    Lonial, Sagar
    Kaufman, Jonathan
    Laubach, Jacob
    Richardson, Paul
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2013, 13 (12) : 1731 - 1740
  • [30] Effects of Intermediate Doses of Glucocorticoids on Bone Turnover and Circulating Dkk-1, MIF, sRANKL, and OPG in Patients with Interstitial Lung Disease. A Three-Month Longitudinal Study
    Dovio, A.
    Palmas, E.
    Saba, L.
    Termine, A.
    Bianco, E.
    Mercante, L.
    Albera, C.
    Angeli, A.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S218 - S218