Autonomous fueled mechanical replication of nucleic acid templates for the amplified optical detection of DNA

被引：61
|
作者：
Weizmann, Y [1 ]
Cheglakov, Z [1 ]
Pavlov, V [1 ]
Willner, I [1 ]
机构：
[1] Hebrew Univ Jerusalem, Inst Chem, Farkas Ctr Light Induced Proc, IL-91904 Jerusalem, Israel
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 14期
关键词：
DNA; enzymes; fluorescence; self-replication;
D O I：
10.1002/anie.200503810
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) Fuel for a DNA machine: A Fokl enzyme/DNA scission machine is triggered by the hybridization of its DNA hairpin structure with a target nucleic acid. The machine is fueled by a secondary fluorophore (F)- and quencher (Q)-functionalized nucleic acid 2. Scission of 3 leads to replication of the machinery cutter 1 and yields a fluorescent product 6, which provides an optical output for the machine (see scheme). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2238 / 2242
页数：5
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