Targeting Ornithine Decarboxylase for the Prevention of Nonmelanoma Skin Cancer in Humans

被引：36
|
作者：
Elmets, Craig A. [1 ]
Athar, Mohammad
机构：
[1] Univ Alabama Birmingham, Dept Dermatol, UAB Skin Dis Res Ctr, Birmingham, AL 35294 USA
来源：
CANCER PREVENTION RESEARCH | 2010年 / 3卷 / 01期
关键词：
SQUAMOUS-CELL CARCINOMAS; BASAL-CELL; ALPHA-DIFLUOROMETHYLORNITHINE; XERODERMA-PIGMENTOSUM; COX-2; EXPRESSION; SUNSCREEN USE; DOUBLE-BLIND; CHEMOPREVENTION; CARCINOGENESIS; KERATOSES;
D O I：
10.1158/1940-6207.CAPR-09-0248
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bailey et al. report in this issue of the journal (beginning on page 35) one of the first successful trials of basal cell carcinoma (BCC) prevention. Oral alpha-difluoromethyl-dl-ornithine (DFMO) reduced new BCCs in patients with a prior history of nonmelanoma skin cancer. DFMO is an inhibitor of ornithine decarboxylase, a key enzyme in the polyamine biosynthetic pathway. This perspective on Bailey et al. discusses our knowledge of the contribution of polyamines to BCC pathogenesis, how this knowledge advanced the development of a new method to prevent BCCs, and prospects for future studies of DFMO in BCC prevention. Cancer Prev Res; 3(1); 8-11. (c) 2010 AACR.
引用
收藏
页码：8 / 11
页数：4
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