Synthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3',2':4,5]-Thieno[3,2-D]Pyrimidine Derivatives

被引：1
|
作者：
Dabaeva, V. V. [1 ]
Bagdasaryan, M. R. [1 ]
Paronikyan, E. G. [1 ]
Dashyan, Sh. Sh. [1 ]
Paronikyan, R. G. [1 ]
Nazaryan, I. M. [1 ]
Akopyan, A. G. [1 ]
机构：
[1] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, 26 Azatutyan Prospekt, Erevan 0014, Armenia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2020年 / 54卷 / 07期
关键词：
synthesis; cyclopentanopyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidine; neurotropic activity; OPEN-FIELD; ANXIETY; DRUGS; RATS;
D O I：
10.1007/s11094-020-02259-y
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2-Oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine was used as the starting point to develop an accessible synthesis of condensed cyclopentanopyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives. The neurotropic activity of these compounds was studied, and a number of them showed anticonvulsant activity as antagonism to corasol. CompoundII, like diazepam, had anti-anxiety and activating effects, while the other compounds had sedative activity.
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页码：707 / 713
页数：7
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