Synthesis and Neurotropic Activity of Novel Condensed Cyclopentanopyrido[3',2':4,5]-Thieno[3,2-D]Pyrimidine Derivatives

被引：1

作者：

Dabaeva, V. V. ^{[1
]}

Bagdasaryan, M. R. ^{[1
]}

Paronikyan, E. G. ^{[1
]}

Dashyan, Sh. Sh. ^{[1
]}

Paronikyan, R. G. ^{[1
]}

Nazaryan, I. M. ^{[1
]}

Akopyan, A. G. ^{[1
]}

机构：

[1] Natl Acad Sci Republ Armenia, Sci & Technol Ctr Organ & Pharmaceut Chem, 26 Azatutyan Prospekt, Erevan 0014, Armenia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2020年 / 54卷 / 07期

关键词：

synthesis; cyclopentanopyrido[3 ',2 ':4,5]thieno[3,2-d]pyrimidine; neurotropic activity; OPEN-FIELD; ANXIETY; DRUGS; RATS;

D O I：

10.1007/s11094-020-02259-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

2-Oxo-2,5,6,7-tetrahydro-3-cyano-1H-cyclopenta[b]pyridine was used as the starting point to develop an accessible synthesis of condensed cyclopentanopyrido[3',2':4,5]thieno[3,2-d]pyrimidine derivatives. The neurotropic activity of these compounds was studied, and a number of them showed anticonvulsant activity as antagonism to corasol. CompoundII, like diazepam, had anti-anxiety and activating effects, while the other compounds had sedative activity.

引用

页码：707 / 713

页数：7

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