A Novel Method of Mobilizing Leukemia Initiating Cells by a Small Molecule Cdc42 Activity-Specific Inhibitor (CASIN) for Acute Myeloid Leukemia Therapy

被引：0
|
作者：
Liu, Wei [1 ]
Mizukawa, Benjamin [2 ]
Wunderlich, Mark
Johnson, James F.
Mulloy, James C.
Zheng, Yi
机构：
[1] Cincinnati Childrens Hosp Med Ctr, Mol & Dev Biol Program, Div Expt Hematol & Canc Biol, Cincinnati, OH USA
[2] Cincinnati Childrens Hosp Med Ctr, Canc & Blood Dis Inst, Cincinnati, OH USA
来源：
BLOOD | 2009年 / 114卷 / 22期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：11 / 11
页数：1
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    Anderson, Dan
    Wustrow, David
    Zhou, Han-Jie
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    Kelly, Kevin R.
    Saunthararajah, Yogen
    Advani, Anjali S.
    Maciejewski, Jaroslaw P.
    Sekeres, Mikkael A.
    Nawrocki, Steffan T.
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  • [23] SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
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    Stopeck, AT
    Silverman, LR
    Lancet, JE
    Cooper, MA
    Hannah, AK
    Cherrington, JM
    O'Farrell, AM
    Yuen, HA
    Louie, SG
    Hong, W
    Cortes, JE
    Verstovsek, S
    Albitar, M
    O'Brien, SM
    Kantarjian, HM
    Karp, JE
    [J]. BLOOD, 2003, 102 (03) : 795 - 801
  • [24] MLN4924, A Novel First in Class Small Molecule Inhibitor of the Nedd8 Activating Enzyme (NAE), Has Potent Activity in Preclinical Models of Acute Myeloid Leukemia.
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    Nawrocki, Steffan T.
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    Ruiz, Marcos J.
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    Konopleva, M
    Deng, XM
    Harris, D
    Ruvolo, P
    Estrov, Z
    May, WS
    Rosenberg, SH
    Andreeff, M
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    Rousseau, Raphael
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    Biagi, Ettore
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    Hill, A. A.
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    Frye, S. V.
    Earp, H. S.
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