Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

被引：10
|
作者：
Fruscella, P [1 ]
Romano, M [1 ]
Albani, D [1 ]
Bernasconi, S [1 ]
Luini, W [1 ]
Bruno, A [1 ]
Salmona, M [1 ]
Diomede, L [1 ]
机构：
[1] Mario Negri Inst Pharmacol Res, Dept Mol Pharmacol & Biochem, I-20157 Milan, Italy
来源：
CYTOKINE | 2000年 / 12卷 / 07期
关键词：
chemokines; cholesterol; HMG-CoA reductase; MCP-1; rodent;
D O I：
10.1006/cyto.1999.0602
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.
引用
收藏
页码：1100 / 1103
页数：4
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