Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

被引：10

作者：

Fruscella, P ^{[1
]}

Romano, M ^{[1
]}

Albani, D ^{[1
]}

Bernasconi, S ^{[1
]}

Luini, W ^{[1
]}

Bruno, A ^{[1
]}

Salmona, M ^{[1
]}

Diomede, L ^{[1
]}

机构：

[1] Mario Negri Inst Pharmacol Res, Dept Mol Pharmacol & Biochem, I-20157 Milan, Italy

来源：

CYTOKINE | 2000年 / 12卷 / 07期

关键词：

chemokines; cholesterol; HMG-CoA reductase; MCP-1; rodent;

D O I：

10.1006/cyto.1999.0602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

引用

页码：1100 / 1103

页数：4

共 50 条

[31] Molecular docking and ADMET analysis of synthetic statins for HMG-CoA reductase inhibition activity
Toppo, Aditya L.
Yadav, Manisha
Dhagat, Swasti
Ayothiraman, Seenivasan
Eswari, Jujjavarapu Satya
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS, 2021, 58 (02): : 127 - 134
[32] HMG-COA REDUCTASE - ROLE IN SCHISTOSOME EGG-PRODUCTION
BENNETT, JL
VANDEWAA, E
JOURNAL OF CELLULAR BIOCHEMISTRY, 1986, : 158 - 158
[33] REGULATION OF HAMSTER ADRENAL HMG-COA REDUCTASE-ACTIVITY
LEHOUX, JG
PREISS, B
JOURNAL OF LIPID RESEARCH, 1979, 20 (08) : 1047 - 1047
[34] MODULATION OF HMG-COA REDUCTASE-ACTIVITY BY PANTETHEINE PANTETHINE
CIGHETTI, G
DELPUPPO, M
PARONI, R
KIENLE, MG
BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 963 (02) : 389 - 393
[35] HMG-COA REDUCTASE-ACTIVITY IN ADRENOCORTICAL TISSUE PREPARATION
LEHOUX, JG
TAN, L
PREISS, B
GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1976, 29 (02) : 257 - 258
[36] Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts
Menéndez, R
Amor, AM
Rodeiro, I
González, RM
González, PC
Alfonso, JL
Más, R
ARCHIVES OF MEDICAL RESEARCH, 2001, 32 (01) : 8 - 12
[37] Genetically Predicted Inhibition of HMG-CoA Reductase Reduces Risk of DNMT3A Clonal Hematopoiesis
Carter, Paul R.
Gozdecka, Malgorzata
Quiros, Pedro
Lockhart, Samuel M.
Gray, Victoria
Richenberg, George
Owen, Carina
Jansen, Joop
van Bergen, Maaike
Larsson, Susanna
Huntly, Brian
CIRCULATION, 2023, 148
[38] HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo
Han, KH
Ryu, J
Hong, KH
Ko, JS
Pak, YK
Kim, JB
Park, SW
Kim, JJ
CIRCULATION, 2005, 111 (11) : 1439 - 1447
[39] Inhibition of TLR8 signalling by HMG-CoA reductase inhibitors
Mullen, L.
Sacre, S.
Ferdjani, J.
IMMUNOLOGY, 2014, 143 : 136 - 137
[40] INHIBITION OF MICROSOMAL AND SOLUBLE HMG-COA REDUCTASE BY OLEIC-ACID AND OLEOYL COA
LEHRER, GM
PANINI, SR
ROGERS, DH
RUDNEY, H
JOURNAL OF LIPID RESEARCH, 1979, 20 (08) : 1047 - 1047

← 1 2 3 4 5 →