Inhibition of HMG-CoA reductase activity by hypercholesterolaemia reduces leukocyte recruitment and MCP-1 production

被引：10

作者：

Fruscella, P ^{[1
]}

Romano, M ^{[1
]}

Albani, D ^{[1
]}

Bernasconi, S ^{[1
]}

Luini, W ^{[1
]}

Bruno, A ^{[1
]}

Salmona, M ^{[1
]}

Diomede, L ^{[1
]}

机构：

[1] Mario Negri Inst Pharmacol Res, Dept Mol Pharmacol & Biochem, I-20157 Milan, Italy

来源：

CYTOKINE | 2000年 / 12卷 / 07期

关键词：

chemokines; cholesterol; HMG-CoA reductase; MCP-1; rodent;

D O I：

10.1006/cyto.1999.0602

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the relationship between cholesterol homeostasis and inflammation we studied the effect of hypercholesterolaemia on in vivo cytokine production and leukocyte migration, in a murine model of local inflammation. Hypercholesterolaemia reduced of 40% the leukocyte recuitment by inhibiting interleukin-6 and monocyte chemotactic protein-1 production in the pouch exudate, without affecting vascular permeability or leukocytes motility. (C) 2000 Academic Press.

引用

页码：1100 / 1103

页数：4

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