Total Synthesis of Cladoniamide G

被引：34
|
作者：
Loosley, Benjamin C. [1 ]
Andersen, Raymond J. [1 ]
Dake, Gregory R. [1 ]
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 05期
基金：
加拿大创新基金会; 加拿大自然科学与工程研究理事会;
关键词：
BIOSYNTHESIS;
D O I：
10.1021/ol400055v
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The total synthesis of cladoniamide G, a cytotoxic compound against MCF-7 breast cancer cells (10 mu g/mL), was accomplished. Key steps in the sequence include oxidative dimerization of 3-acetoxy-5-chloroindole and a tandem process incorporating three steps: bimolecular carbonyl addition, lactam formation, and carbamate removal.
引用
收藏
页码：1152 / 1154
页数：3
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