Hippocampal slices from prion protein null mice: Disrupted Ca2+-activated K+ currents

被引：153
|
作者：
Colling, SB
Collinge, J
Jefferys, JGR
机构：
[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, DEPT PHYSIOL & BIOPHYS, LONDON W2 1PG, ENGLAND
[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, DEPT BIOCHEM & MOLEC GENET, LONDON W2 1PG, ENGLAND
[3] UNIV BIRMINGHAM, SCH MED, DEPT PHYSIOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND
来源：
NEUROSCIENCE LETTERS | 1996年 / 209卷 / 01期
基金：
英国惠康基金;
关键词：
prion disease; hippocampus; intrinsic properties; afterhyperpolarization; potassium channels; I-AHP channel;
D O I：
10.1016/0304-3940(96)12596-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that Ca2+-activated K+ currents, in particular I-AHP, are disrupted in PrP-null mice.
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页码：49 / 52
页数：4
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