Hippocampal slices from prion protein null mice: Disrupted Ca2+-activated K+ currents

被引：153

作者：

Colling, SB

Collinge, J

Jefferys, JGR

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, DEPT PHYSIOL & BIOPHYS, LONDON W2 1PG, ENGLAND

[2] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, ST MARYS HOSP, SCH MED, DEPT BIOCHEM & MOLEC GENET, LONDON W2 1PG, ENGLAND

[3] UNIV BIRMINGHAM, SCH MED, DEPT PHYSIOL, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

NEUROSCIENCE LETTERS | 1996年 / 209卷 / 01期

基金：

英国惠康基金;

关键词：

prion disease; hippocampus; intrinsic properties; afterhyperpolarization; potassium channels; I-AHP channel;

D O I：

10.1016/0304-3940(96)12596-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The intrinsic properties of hippocampal CA1 pyramidal cells were examined in mice lacking prion protein (PrP-null). The resting potentials, time constants, amplitude of the medium afterhyperpolarization (AHP) and spike firing accommodation did not differ from the control group. The PrP-null group differed in having lower input resistances, a lack of the late AHP and of a charybdotoxin-sensitive summated AHP. We propose that Ca2+-activated K+ currents, in particular I-AHP, are disrupted in PrP-null mice.

引用

页码：49 / 52

页数：4

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