Synthesis of pyridinone ribonucleoside 3'-O-phosphoramidites and their incorporation into oligoribonucleotides

被引：17

作者：

MatulicAdamic, J ^{[1
]}

Gonzalez, C ^{[1
]}

Usman, N ^{[1
]}

Beigelman, L ^{[1
]}

机构：

[1] RIBOZYME PHARMACEUT INC,DEPT CHEM & BIOCHEM,BOULDER,CO 80301

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 04期

关键词：

D O I：

10.1016/0960-894X(96)00030-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Protected pyridin-2- and pyridin-4-one ribonucleosides 3 and 9 were synthesized using a one-pot reaction of silylated bases with 1-O-acetyl-tri-O-benzoyl-beta-D-ribofuranose (2) in the presence of CF(3)SO(3)SiMe(3) The nucleosides were converted in 4 steps into 3'-O-phosphoramidites 7 and 11 which were incorporated into hammerhead ribozyme substrates using solid-phase phosphoramidite chemistry.

引用

页码：373 / 378

页数：6

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