The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

被引：26

作者：

Suh, YG

Kim, SN

Shin, DY

Hyun, SS

Lee, DS

Min, KH

Han, SM

Li, FN

Choi, EC

Choi, SH

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Korea Adv Inst Sci & Technol, Life Sci Div, Seoul 130650, South Korea

[3] Dong A Pharmaceut Co, Res Labs, Yongin 449900, Kyunggi, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期

关键词：

MRSA; mansonone F; anti-bacterial agent; sesquiterpenoid quinone;

D O I：

10.1016/j.bmcl.2005.09.024

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin. (c) 2005 Published by Elsevier Ltd.

引用

页码：142 / 145

页数：4

共 25 条

[1] Structure-activity relationship of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on C6 and C9 analogues.
Suh, YG
Kim, SN
Shin, DY
Hyun, SS
Min, KH
Lee, YS
Kim, SH
Paek, SM
Jung, JW
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U173 - U174
[2] Syntheses and anti-MRSA activities of the C3 analogs of mansonone F, a potent anti-bacterial sesquiterpenoid: insights into its structural requirements for anti-MRSA activity
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Kim, SN
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Seo, SY
Lee, YS
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[3] Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (14) : 1945 - 1950
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BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (03) : 630 - 636
[7] Design, Synthesis and Structure-activity Relationship Study of a Series of Bis(bibenzyl)-type Natural Products, Riccardin C Derivatives, as Candidate Anti-MRSA Agents
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[8] Structure-activity relationships of the antimalarial agent artemisinin .5. Analogs of 10-deoxoartemisinin substituted at C-3 and C-9
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[9] Structure-activity relationship studies on new DABOs: effect of substitutions at pyrimidine C-5 and C-6 positions on anti-HIV-1 activity
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[10] 1-phenylpyrazolo[3,4-d]pyrimidines;: Structure-activity relationships for C6 substituents at A1 and A2A adenosine receptors
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