The structure-activity relationships of mansonone F, a potent anti-MRSA sesquiterpenoid quinone: SAR studies on the C6 and C9 analogs

被引：26
|
作者：
Suh, YG
Kim, SN
Shin, DY
Hyun, SS
Lee, DS
Min, KH
Han, SM
Li, FN
Choi, EC
Choi, SH
机构：
[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea
[2] Korea Adv Inst Sci & Technol, Life Sci Div, Seoul 130650, South Korea
[3] Dong A Pharmaceut Co, Res Labs, Yongin 449900, Kyunggi, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 01期
关键词：
MRSA; mansonone F; anti-bacterial agent; sesquiterpenoid quinone;
D O I：
10.1016/j.bmcl.2005.09.024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For the systematic SAR study on mansonone F, a series of C6 and C9 analogs of mansonone F have been synthesized and their anti-MRSA activities were evaluated. Most of the analogs exhibited good or excellent anti-MRSA activities. In particular, the 6-n-butylmansonone F showed fourfold higher antibacterial activities compared to that of vancomycin. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：142 / 145
页数：4
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