Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

被引：33
|
作者：
Ares, JJ
Outt, PE
Randall, JL
Johnston, JN
Murray, PD
OBrien, LM
Weisshaar, PS
Ems, BL
机构：
[1] Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45253-8707
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 08期
关键词：
D O I：
10.1016/0960-894X(96)00134-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：995 / 998
页数：4
相关论文
共 50 条
  • [41] Synthesis and Activity Evaluation of Novel Prenylated Flavonoids as Antiproliferative Agents
    Kingsadingthongkham Vongdeth
    Liqiong Ran
    Lili Yan
    Qiuan Wang
    Chemical Research in Chinese Universities, 2018, 34 : 564 - 570
  • [42] Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds
    Antonello, A
    Hrelia, P
    Leonardi, A
    Marucci, G
    Rosini, M
    Tarozzi, A
    Tumiatti, V
    Melchiorre, C
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (01) : 28 - 31
  • [43] Inhibitors of apoptosis in lymphocytes:: Synthesis and biological evaluation of compounds related to pifithrin-α
    Barchéchath, SD
    Tawatao, RI
    Corr, M
    Carson, DA
    Cottam, HB
    JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (20) : 6409 - 6422
  • [44] NOVEL LINKED ANTIVIRAL AND ANTITUMOR AGENTS RELATED TO NETROPSIN AND DISTAMYCIN - SYNTHESIS AND BIOLOGICAL EVALUATION
    LOWN, JW
    KROWICKI, K
    BALZARINI, J
    NEWMAN, RA
    DECLERCQ, E
    JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (10) : 2368 - 2375
  • [45] Synthesis and Biological Evaluation of Potent Antifungal Agents
    Geronikaki, Athina
    Fesatidou, Maria
    Kartsev, Victor
    Macaev, Fliur
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2013, 13 (21) : 2684 - 2733
  • [46] Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha
    Cottam, HB
    Shih, HC
    Tehrani, LR
    Wasson, DB
    Carson, DA
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) : 2 - 9
  • [47] Synthesis and biological evaluation of thiobenzanilides as anticancer agents
    Hu, Wan-Ping
    Yu, Hsin-Su
    Chen, Yan-Ren
    Tsai, Yi-Min
    Chen, Yin-Kai
    Liao, Chao-Cheng
    Chang, Long-Sen
    Wang, Jeh-Jeng
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (09) : 5295 - 5302
  • [48] Synthesis and Biological Evaluation of Potential Oncoimmunomodulator Agents
    Gil-Edo, Raquel
    Espejo, Sara
    Falomir, Eva
    Carda, Miguel
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (03)
  • [49] Design, synthesis and biological evaluation of novel pyrazole-based compounds as potential chemotherapeutic agents
    Jaballah, Maiy Y.
    Elleboudy, Nooran S.
    Sharaky, Marwa
    Abouzid, Khaled A.
    Shahin, Mai, I
    FUTURE MEDICINAL CHEMISTRY, 2024, 16 (13) : 1299 - 1311
  • [50] Synthesis and biological evaluation of some new heterocyclic compounds incorporating sulfapyridine as potential antimicrobial agents
    El-Gendy, Samar M.
    Keshk, Eman M.
    Khalil, Abdel-Galil M.
    Fekri, Ahmed
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1322
12345