Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

被引：33
|
作者：
Ares, JJ
Outt, PE
Randall, JL
Johnston, JN
Murray, PD
OBrien, LM
Weisshaar, PS
Ems, BL
机构：
[1] Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45253-8707
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 08期
关键词：
D O I：
10.1016/0960-894X(96)00134-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：995 / 998
页数：4
相关论文
共 50 条
  • [21] Synthesis and Biological Evaluation of Flavonoids as Antiacetylcholinesterase Agent
    Ibrahim, Saleh Nazifi
    Ahmad, Farediah
    JURNAL TEKNOLOGI, 2014, 69 (01):
  • [22] Flavonoids as Vasorelaxant Agents: Synthesis, Biological Evaluation and Quantitative Structure Activities Relationship (QSAR) Studies
    Dong, Xiaowu
    Wang, Yanming
    Liu, Tao
    Wu, Peng
    Gao, Jiadi
    Xu, Jianchao
    Yang, Bo
    Hu, Yongzhou
    MOLECULES, 2011, 16 (10): : 8257 - 8272
  • [23] Synthesis and biological evaluation of cinitapride related derivatives as potential prokinetic agents
    Srinivasulu, G
    Reddy, PP
    Hegde, P
    Chakrabart, R
    HETEROCYCLIC COMMUNICATIONS, 2005, 11 (01) : 23 - 28
  • [24] Synthesis and evaluation of beta-hydroxytriazoles and related compounds as antitubercular agents
    Menendez, Christophe
    Mori, Giorgia
    Maillot, Mathilde
    Fabing, Isabelle
    Carayon, Chantal
    Orena, Beatrice Silvia
    Pasca, Maria Rosalia
    Voitenko, Zoia
    Lherbet, Christian
    Baltas, Michel
    FRENCH-UKRAINIAN JOURNAL OF CHEMISTRY, 2015, 3 (01): : 82 - 96
  • [25] Synthesis and biological evaluation of new Camptothecin-like compounds as anticancer agents
    Madkour, Moustafa M.
    Sebastian, Anusha
    Ramadan, Wafaa S.
    Menon, Varsha
    Lozon, Lama
    Srikanth, Gourishetty
    Tarazi, Hamadeh
    El-Gamal, Mohammed I.
    Al-Tel, Taleb H.
    El-Awady, Raafat
    JOURNAL OF MOLECULAR STRUCTURE, 2025, 1328
  • [26] Polycyclic aromatic compounds as anticancer agents: Synthesis and biological evaluation of dibenzofluorene derivatives
    Becker, FF
    Mukhopadhyay, C
    Hackfeld, L
    Banik, I
    Banik, BK
    BIOORGANIC & MEDICINAL CHEMISTRY, 2000, 8 (12) : 2693 - 2699
  • [27] Synthesis and biological evaluation of resveratrol–coumarin hybrid compounds as potential antitumor agents
    Wei Shen
    Jianfeng Mao
    Juan Sun
    Minjie Sun
    Can Zhang
    Medicinal Chemistry Research, 2013, 22 : 1630 - 1640
  • [28] Synthesis and biological evaluation of novel sulfonanilide compounds as antiproliferative agents for breast cancer
    Su, Bin
    Darby, Michael V.
    Brueggerneier, Robert W.
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2008, 10 (03): : 475 - 483
  • [29] Synthesis, Biological Evaluation and Docking Study of New Pyrimidine Compounds as Anticancer Agents
    Boumi, Shahin
    Moghimirad, Jafar
    Ostad, Seyed Nasser
    Amanlou, Massoud
    Tavajohi, Shohreh
    Amini, Mohsen
    DRUG RESEARCH, 2021, 71 (05) : 284 - 290
  • [30] Hypervalent Iodine Reagents in the Synthesis of Flavonoids and Related Compounds
    Kumar, Rajesh
    Sharma, Nitya
    Prakash, Om
    CURRENT ORGANIC CHEMISTRY, 2020, 24 (18) : 2031 - 2047
12345