Synthesis and biological evaluation of flavonoids and related compounds as gastroprotective agents

被引：33
|
作者：
Ares, JJ
Outt, PE
Randall, JL
Johnston, JN
Murray, PD
OBrien, LM
Weisshaar, PS
Ems, BL
机构：
[1] Procter and Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45253-8707
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 08期
关键词：
D O I：
10.1016/0960-894X(96)00134-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several analogs of the gastroprotective molecule flavone have been synthesized and evaluated for gastroprotective activity. A C2-C3 double bond and an intact C ring appear necessary for optimum activity. Activity can be retained by replacing the 2-phenyl substituent with other groups but is eliminated when this ring is moved from the 2- to the 3-position. Copyright (C) 1996 Elsevier Science Ltd
引用
收藏
页码：995 / 998
页数：4
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