The Cytotoxic Activity of Diterpenoids from Isodon species

被引：0
|
作者：
Ohsaki, Ayumi [1 ]
Ozawa, Masaaki [1 ]
Komiyama, Kanki [3 ]
Kishida, Akio [1 ]
Isobe, Takahiko [2 ]
机构：
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
[2] Hyogo Univ Hlth Sci, Gen Educ Ctr, Dept Chem, Chuo Ku, Kobe, Hyogo 6508530, Japan
[3] Kitasato Res Ctr Environm Sci, Minami Ku, Sagamihara, Kanagawa 2520329, Japan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期
关键词：
Cytotoxicity; Isodon; Dihydroenmein; Trichorabdal B; Kamebanin; Vincristine-resistant P388;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.
引用
收藏
页码：977 / 978
页数：2
相关论文
共 50 条
  • [31] Diterpenoids from Isodon excisoides
    Zhang, Ji Xia
    Wang, Yong Xue
    He, Zhi An
    Yan, Fu Lin
    JOURNAL OF CHEMICAL RESEARCH, 2009, (01) : 35 - 37
  • [32] Diterpenoids from Isodon eriocalyx
    Chen, SN
    Yue, JM
    Chen, SY
    Lin, ZW
    Qin, GW
    Sun, HD
    Chen, YZ
    JOURNAL OF NATURAL PRODUCTS, 1999, 62 (05): : 782 - 784
  • [33] Diterpenoids from Isodon eriocalyx
    Chen, NY
    Tian, MQ
    Wu, R
    Sun, HD
    Li, CM
    Lin, ZW
    JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2000, 47 (02) : 363 - 366
  • [34] Diterpenoids from Isodon sculponeatus
    姜北
    梅双喜
    赵爱华
    孙汉董
    吕扬
    郑启泰
    Chinese Journal of Chemistry, 2002, (09) : 887 - 890
  • [35] Diterpenoids from Isodon sculponeatus
    Jiang, Hua-Yi
    Wang, Wei-Guang
    Zhou, Min
    Wu, Hai-Yan
    Zhan, Rui
    Li, Xiao-Nian
    Du, Xue
    Li, Yan
    Pu, Jian-Xin
    Sun, Han-Dong
    FITOTERAPIA, 2014, 93 : 142 - 149
  • [36] Diterpenoids from Isodon eriocalyx
    Wang, J
    Lin, ZW
    Zhao, QS
    Sun, HD
    PHYTOCHEMISTRY, 1998, 47 (02) : 307 - 309
  • [37] Diterpenoids from Isodon leucophyllus
    Chen, SN
    Lin, ZW
    Qin, GW
    Sun, HD
    Chen, YZ
    PLANTA MEDICA, 1999, 65 (05) : 472 - 474
  • [38] Diterpenoids from Isodon glutinosus
    Huang, H
    Chen, YP
    Zhang, HJ
    Lin, ZW
    Zhao, SX
    Wang, MS
    Fujita, T
    Sun, HD
    PHYTOCHEMISTRY, 1997, 45 (03) : 559 - 562
  • [39] Diterpenoids from Isodon parvifolius
    Yang, Libin
    Liu, Shaojing
    Wang, Honglun
    Suo, Yourui
    RECORDS OF NATURAL PRODUCTS, 2015, 9 (04) : 526 - 529
  • [40] ANTITUMOR ACTIVITY OF ISODON DITERPENOIDS - STRUCTURAL REQUIREMENTS FOR ACTIVITY
    FUJITA, E
    NAGAO, Y
    NODE, M
    KANEKO, K
    NAKAZAWA, S
    KURODA, H
    EXPERIENTIA, 1976, 32 (02): : 203 - 206
12345