The Cytotoxic Activity of Diterpenoids from Isodon species

被引：0
|
作者：
Ohsaki, Ayumi [1 ]
Ozawa, Masaaki [1 ]
Komiyama, Kanki [3 ]
Kishida, Akio [1 ]
Isobe, Takahiko [2 ]
机构：
[1] Tokyo Med & Dent Univ, Inst Biomat & Bioengn, Chiyoda Ku, Tokyo 1010062, Japan
[2] Hyogo Univ Hlth Sci, Gen Educ Ctr, Dept Chem, Chuo Ku, Kobe, Hyogo 6508530, Japan
[3] Kitasato Res Ctr Environm Sci, Minami Ku, Sagamihara, Kanagawa 2520329, Japan
来源：
NATURAL PRODUCT COMMUNICATIONS | 2012年 / 7卷 / 08期
关键词：
Cytotoxicity; Isodon; Dihydroenmein; Trichorabdal B; Kamebanin; Vincristine-resistant P388;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Fifteen Isodon diterpenoids (1-15) were evaluated for their cytotoxic activity against HeLa and HL-60 human cancer cell lines, and against murine vincristine (VCR)-resistant P388 cells. Kamebanin (14) showed efficient cytotoxic activity against HeLa and HL-60 cells. In addition, although dihydroenmein (2) and trichorabdal B (7) were inactive against several tested cell types, they were found to have cytotoxic-enhancing activity of VCR against VCR-resistant P388 cells.
引用
收藏
页码：977 / 978
页数：2
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