Synthesis of macrocycles containing 1,3,4-oxadiazole and pyridine moieties

被引：7
|
作者：
Poojari, Subba [1 ]
Naik, P. Parameshwar [2 ]
Krishnamurthy, G. [2 ]
机构：
[1] Syngene Int Ltd, Bangalore 560099, Karnataka, India
[2] Sahyadri Sci Coll Autonomous, Dept PG Studies & Res Chem, Shimoga 577203, India
来源：
TETRAHEDRON LETTERS | 2014年 / 55卷 / 02期
关键词：
Macrocycles; Oxadiazoles; Pyridine; Aminoacids; PEPTIDES;
D O I：
10.1016/j.tetlet.2013.08.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of peptide-like 25-28 membered macrocycles containing 1,3,4-oxadiazoles and pyridines bearing a chiral center scaffold have been synthesized by using known coupling reagents and common protecting groups. The yield of the purified macrocycles was poor on an average, yet it seems to be independent of amino acid substitution or stereochemistry. These macrocycles represent a new class of structures for further development and for future application in high-throughput screening against a variety of biological targets. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：305 / 309
页数：5
相关论文
共 50 条
  • [31] SYNTHESIS OF NEW DERIVATIVES OF 1,3,4-OXADIAZOLE
    GREKOV, AP
    NESYNOV, EP
    JOURNAL OF GENERAL CHEMISTRY USSR, 1961, 31 (04): : 1037 - &
  • [32] SYNTHESIS AND CHARACTERIZATION OF 1,3,4-OXADIAZOLE DERIVATIVES
    Rodrigues, Iola Sandria
    Badarinath, A. V.
    Revanasiddappa, B. C.
    HETEROCYCLIC LETTERS, 2020, 10 (03): : 467 - 470
  • [33] SYNTHESIS OF SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES
    Mickevicius, V.
    Vaickelioniene, R.
    Sapijanskaite, B.
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2009, 45 (02) : 215 - 218
  • [34] Aromatic polyethers containing 1,3,4-oxadiazole rings
    Hamciuc, C
    Hamciuc, E
    Vlad-Bubulac, T
    Petreus, O
    REVUE ROUMAINE DE CHIMIE, 2006, 51 (01) : 53 - 59
  • [35] Design, Synthesis and Biological Activities of Compounds Containing 1,3,4-Oxadiazole or 1,3,4-Thiadiazole
    Yan, Longjia
    Li, Yongliang
    Deng, Minggao
    Chen, Anchao
    Du, Zhiyun
    Dong, Changzhi
    Chen, Huixiong
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2020, 40 (03) : 731 - 739
  • [36] Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds
    Joshi, Kaushik
    Mahida, Anil
    Rathod, Jayant
    INDIAN JOURNAL OF CHEMISTRY, 2023, 62 (03): : 237 - 243
  • [37] Copoly(peryleneimide)s Containing 1,3,4-Oxadiazole Rings: Synthesis and Properties
    Rusu, Radu-Dan
    Damaceanu, Mariana-Dana
    Marin, Luminita
    Bruma, Maria
    JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2010, 48 (19) : 4230 - 4242
  • [38] Design, synthesis and antifungal activity of indole derivatives containing 1,3,4-oxadiazole
    He, Bangcan
    Hu, Yuzhi
    Mao, Piao
    Deng, Tianyu
    Wang, Yuhong
    Luo, Xingping
    Zou, Hongqian
    Wang, Zhenchao
    Xue, Wei
    ARABIAN JOURNAL OF CHEMISTRY, 2024, 17 (05)
  • [39] Nonlinear Optical Studies of Newly Synthesized Polythiophenes Containing Pyridine and 1,3,4-Oxadiazole Units
    Poornesh, P.
    Hegde, P. K.
    Manjunatha, M. G.
    Umesh, G.
    Adhikari, A. V.
    POLYMER ENGINEERING AND SCIENCE, 2009, 49 (05): : 875 - 880
  • [40] Synthesis and Antioxidant Activity of Furan Derivatives Containing a 1,3,4-Oxadiazole Ring
    Aghekyan, A. A.
    Panosyan, H. A.
    Buniatyan, Zh. M.
    Muradyan, R. E.
    Mkryan, G. G.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 60 (04) : 655 - 663
12345