Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds

被引：1
|
作者：
Joshi, Kaushik [1 ]
Mahida, Anil [2 ]
Rathod, Jayant [3 ]
机构：
[1] D K V Arts & Sci Coll, Dept Chem, Jamnagar 361008, Gujarat, India
[2] Govt Sci Coll, Dept Chem, Songadh 394670, Gujarat, India
[3] Govt Sci Coll, Dept Chem, Dhanpur 389382, Gujarat, India
来源：
INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 03期
关键词：
Isoxazole; 4-oxadiazole; Biheterocycles; Anti; -fungal; -bacterial; PHARMACOLOGICAL EVALUATION; DERIVATIVES; CONVERSION;
D O I：
10.56042/ijc.v62i3.72063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4-oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c have exhibited significant anti-bacterial activity with MIC 50 mu g/mL against S. pyogenus and S. aureus pathogens, respectively.
引用
收藏
页码：237 / 243
页数：7
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