Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds

被引：1
|
作者：
Joshi, Kaushik [1 ]
Mahida, Anil [2 ]
Rathod, Jayant [3 ]
机构：
[1] D K V Arts & Sci Coll, Dept Chem, Jamnagar 361008, Gujarat, India
[2] Govt Sci Coll, Dept Chem, Songadh 394670, Gujarat, India
[3] Govt Sci Coll, Dept Chem, Dhanpur 389382, Gujarat, India
来源：
INDIAN JOURNAL OF CHEMISTRY | 2023年 / 62卷 / 03期
关键词：
Isoxazole; 4-oxadiazole; Biheterocycles; Anti; -fungal; -bacterial; PHARMACOLOGICAL EVALUATION; DERIVATIVES; CONVERSION;
D O I：
10.56042/ijc.v62i3.72063
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4-oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c have exhibited significant anti-bacterial activity with MIC 50 mu g/mL against S. pyogenus and S. aureus pathogens, respectively.
引用
收藏
页码：237 / 243
页数：7
相关论文
共 50 条
  • [41] Synthesis and properties of photoluminescent copolymer containing 1,3,4-oxadiazole and carbazole rings
    Chen, ZB
    Liu, YF
    Zhang, CH
    Bai, FL
    JOURNAL OF APPLIED POLYMER SCIENCE, 2004, 92 (05) : 2777 - 2783
  • [42] Synthesis and electrooptical properties of novel ppv derivatives containing 1,3,4-oxadiazole
    Kim, YH
    Shin, DC
    Jung, SO
    Kwon, SK
    MOLECULAR CRYSTALS AND LIQUID CRYSTALS, 2003, 405 : 27 - 32
  • [43] Synthesis and Biological Activities of Novel Cyanoacrylates Containing 1,3,4-Oxadiazole Moiety
    Shi, Yujn
    Li, Yang
    Fang, Yuan
    Chen, Jia
    Ye, Linyu
    Ge, Shushan
    Dai, Hong
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2016, 36 (10) : 2472 - 2478
  • [44] The synthesis and optical properties of novel triphenylamine containing 1,3,4-oxadiazole derivatives
    Majumdar, K. C.
    Shyam, Pranab K.
    Biswas, Avijit
    De, Swati
    JOURNAL OF LUMINESCENCE, 2013, 143 : 321 - 327
  • [45] Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
    Jian Wu
    Shenghong Kang
    Lijun Luo
    Qingcai Shi
    Juan Ma
    Juan Yin
    Baoan Song
    Deyu Hu
    Song Yang
    Chemistry Central Journal, 7
  • [46] Synthesis and antifungal activities of novel nicotinamide derivatives containing 1,3,4-oxadiazole
    Wu, Jian
    Kang, Shenghong
    Luo, Lijun
    Shi, Qingcai
    Ma, Juan
    Yin, Juan
    Song, Baoan
    Hu, Deyu
    Yang, Song
    CHEMISTRY CENTRAL JOURNAL, 2013, 7
  • [47] Synthesis and Bioactivities of Novel 1,3,4-oxadiazole Derivatives Containing Pyridine Moiety
    Sun, Guo-Xiang
    Shi, Yan-Xia
    Sun, Zhao-Hui
    Yang, Ming-Yan
    Wu, Hong-Ke
    Weng, Jian-Quan
    Tan, Cheng-Xia
    Liu, Xing-Hai
    Li, Bao-Ju
    Zhang, Yong-Gang
    LETTERS IN DRUG DESIGN & DISCOVERY, 2014, 11 (09) : 1119 - 1123
  • [48] Synthesis and electrooptical properties of novel PPV derivatives containing 1,3,4-oxadiazole
    Kwon, S.-K. (skwon@nongae.gsnu.ac.kr), (Taylor and Francis Inc.):
  • [49] Synthesis and Fungicidal Activity of 1,3,4-Oxadiazole Derivatives Containing Pyrazole Moiety
    Sun, Nabo
    Tong, Jianying
    Wu, Hongke
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2013, 33 (01) : 101 - 105
  • [50] Synthesis and characterization of poly(fluorene)-based copolymers containing various 1,3,4-oxadiazole dendritic pendants
    Wu, Chung-Wen
    Tsai, Chien-Min
    Lin, Hong-Cheu
    MACROMOLECULES, 2006, 39 (13) : 4298 - 4305
12345