NIK1, a host factor specialized in antiviral defense or a novel general regulator of plant immunity?

被引：18
|
作者：
Machado, Joao P. B. [1 ]
Brustolini, Otavio J. B. [1 ]
Mendes, Giselle C. [1 ]
Santos, Anesia A. [1 ]
Fontes, Elizabeth P. B. [1 ]
机构：
[1] Univ Fed Vicosa, Natl Inst Sci & Technol Plant Pest Interact, BIOAGRO, Dept Bioquim & Biol Mol, Vicosa, MG, Brazil
来源：
BIOESSAYS | 2015年 / 37卷 / 11期
关键词：
begomoviruses; immune receptor; immune responses; NIK1; NSP-interacting kinase; plant antiviral immunity; translation suppression; RECEPTOR-LIKE KINASES; PROTEIN-KINASE; TYROSINE PHOSPHORYLATION; INNATE IMMUNITY; ARABIDOPSIS; FAMILY; BAK1; BRI1; TRANSLATION; CONTRIBUTES;
D O I：
10.1002/bies.201500066
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NIK1 is a receptor-like kinase involved in plant antiviral immunity. Although NIK1 is structurally similar to the plant immune factor BAK1, which is a key regulator in plant immunity to bacterial pathogens, the NIK1-mediated defenses do not resemble BAK1 signaling cascades. The underlying mechanism for NIK1 antiviral immunity has recently been uncovered. NIK1 activation mediates the translocation of RPL10 to the nucleus, where it interacts with LIMYB to fully down-regulate translational machinery genes, resulting in translation inhibition of host and viral mRNAs and enhanced tolerance to begomovirus. Therefore, the NIK1 antiviral immunity response culminates in global translation suppression, which represents a new paradigm for plant antiviral defenses. Interestingly, transcriptomic analyses in nik1 mutant suggest that NIK1 may suppress antibacterial immune responses, indicating a possible opposite effect of NIK1 in bacterial and viral infections.
引用
收藏
页码：1236 / 1242
页数：7
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