Synthesis of New 3,5-disubstituted-1,2,4-Triazoles and Evaluation of Antibacterial, Antiurease and Antioxidant Activities

被引：0

作者：

Gumrukcuoglu, Nurhan ^{[1
]}

Sokmen, Bahar Bilgin ^{[2
]}

Sahin, Huseyin ^{[3
]}

Ugras, Serpil ^{[4
]}

Sagkal, Yasemin ^{[2
]}

Ugras, Halil Ibrahim ^{[5
]}

机构：

[1] Karadeniz Tech Univ, Vocat Sch Hlth Sci, TR-61080 Trabzon, Turkey

[2] Giresun Univ, Fac Arts & Sci, Dept Chem, TR-28049 Giresun, Turkey

[3] Giresun Univ, Espiye Vocat Sch, TR-28600 Giresun, Turkey

[4] Duzce Univ, Fac Agr & Nat Sci, Dept Field Crops, TR-81620 Duzce, Turkey

[5] Duzce Univ, Fac Arts & Sci, Dept Chem, TR-81620 Duzce, Turkey

来源：

JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2016年 / 38卷 / 05期

关键词：

1,2,4-triazole; Schiff base; Reduction; Urease inhibition activity; Antioxidant activity; STABILITY-CONSTANTS; ANTIELASTASE; DERIVATIVES; BACTERIA; LIGANDS; COMPLEX;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acylhydrazone 2 was synthesized by the condensation of iminoester hydrochloride 1 with acyl hydrazine. The treatment of acylhydrazone with hydrazine hydrate afforded 4-amino-3,5-dialkyl-1,2,4-triazole 3. The treatment of compound 3 with various aromatic aldehydes resulted in the formation of 4-arylidenamino-3, 5-dialkyl-1,2,4-triazoles 4a-c. Sodium borohydride reduction of 4-arylidenamino derivatives afforded 4-alkylamino-3,5-dialkyl- 1,2,4-triazoles 5a-c. The obtained products were identified by FTIR, H-1-NMR, C-13-NMR, Mass spectroscopic and elemental analysis. A series of compounds were evaluated for their, antibacterial, antiurease, antioxidant activities. The results showed that the synthesized new compounds had effective antibacterial, antioxidant, antiurease activities.

引用

页码：928 / 936

页数：9

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