Recent advances in the field of ultrafast laser inscription provide ample evidence underscoring the potential of this technique in fabricating novel and previously unthinkable 2D and 3D photonic and optofluidic platforms enabling current sensor, diagnostics, monitoring and biochemical research to scale new heights. In addition to meeting the demands for compact, active waveguide devices designed for diverse applications such as optical metrology, non-linear microscopy and astrophotonics, this technology facilitates the integration of microfluidics with integrated optics which creates a powerful technology for the manufacture of custom lab-on-chip devices with advanced functionality. This paper highlights the capabilities of ultrafast laser inscription in fabricating novel 3D microfluidic devices aimed for biomedical applications.