Formal total synthesis of (+)-gephyrotoxin

被引：57

作者：

Santarem, Marco ^{[1
]}

Vanucci-Bacque, Corinne ^{[1
]}

Lhommet, Gerard ^{[1
]}

机构：

[1] Univ Paris 06, UPMC, CNRS, Equipe Chim Heterocycles,Lab Chim Organ,UMR 7611, F-75005 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 16期

关键词：

D O I：

10.1021/jo801150e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine beta-enamino ester obtained by condensation of (S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.

引用

页码：6466 / 6469

页数：4

共 50 条

[31] A FORMAL TOTAL SYNTHESIS OF APLYSIATOXIN
OKAMURA, H
KURODA, S
IKEGAMI, S
ITO, Y
KATSUKI, T
YAMAGUCHI, M
TETRAHEDRON LETTERS, 1991, 32 (38) : 5141 - 5142
[32] A formal total synthesis of (-)-limaspermine
Fukuda, Y
Shindo, M
Shishido, K
HETEROCYCLES, 2004, 62 : 787 - 792
[33] Formal total synthesis of aspergillide A
Izuchi, Yuko
Kanomata, Nobuhiro
Koshino, Hiroyuki
Hongo, Yayoi
Nakata, Tadashi
Takahashi, Shunya
TETRAHEDRON-ASYMMETRY, 2011, 22 (02) : 246 - 251
[34] Formal total synthesis of Palmerolide A
Jena, Bighnanshu K.
Mohapatra, Debendra K.
TETRAHEDRON, 2015, 71 (34) : 5678 - 5692
[35] A Formal Total Synthesis of (±)-Rishitinol
Marrugo, Kelly P.
Maldonado, Alexis
Banerjee, Ajoy K.
Cabrera, Elvia, V
ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL, 2020, 52 (05) : 442 - 445
[36] Formal total synthesis of fostriecin
Wang, YG
Kobayashi, Y
ORGANIC LETTERS, 2002, 4 (26) : 4615 - 4618
[37] FORMAL TOTAL SYNTHESIS OF (±)-STRICTAMINE
Sato, Keigo
Takanashi, Noriyuki
Kogure, Noriyuki
Kitajima, Mariko
Takayama, Hiromitsu
HETEROCYCLES, 2018, 97 (01) : 365 - 382
[38] A formal total synthesis of (-)-dysiherbaine
Kang, SH
Lee, YM
SYNLETT, 2003, (07) : 993 - 994
[39] A FORMAL TOTAL SYNTHESIS OF APLYSIN
KHER, SM
KULKARNI, GH
SYNTHETIC COMMUNICATIONS, 1990, 20 (08) : 1241 - 1247
[40] Formal total synthesis of (+)-methynolide
Cossy, J
Bauer, D
Bellosta, V
SYNLETT, 2002, (05) : 715 - 718

← 1 2 3 4 5 →