Formal total synthesis of (+)-gephyrotoxin

被引：57

作者：

Santarem, Marco ^{[1
]}

Vanucci-Bacque, Corinne ^{[1
]}

Lhommet, Gerard ^{[1
]}

机构：

[1] Univ Paris 06, UPMC, CNRS, Equipe Chim Heterocycles,Lab Chim Organ,UMR 7611, F-75005 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 16期

关键词：

D O I：

10.1021/jo801150e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine beta-enamino ester obtained by condensation of (S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.

引用

页码：6466 / 6469

页数：4

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