Differences in the expression of glucose transporter protein isoforms in human retinoblastoma cell lines

被引：1

作者：

Tsukamoto, H ^{[1
]}

Mishima, HK ^{[1
]}

Hirata, K ^{[1
]}

Sato, E ^{[1
]}

Kurokawa, T ^{[1
]}

Ishibashi, S ^{[1
]}

机构：

[1] HIROSHIMA UNIV,SCH MED,DEPT PHYSIOL CHEM,HIROSHIMA 734,JAPAN

来源：

JAPANESE JOURNAL OF OPHTHALMOLOGY | 1997年 / 41卷 / 04期

关键词：

glucose transporter; retinoblastoma; WERI-Rb1; Y79;

D O I：

10.1016/S0021-5155(97)00041-5

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

We investigated the expression of glucose transporter (GLUT) protein isoforms in two human retinoblastoma cell Lines, Y79 and WERI-Rb1, by Western blotting analysis with anti-GLUT1,2,3, and 4 antibodies. GLUT1 and GLUT4 proteins were detected in Y79, whereas GLUT1 and GLUT3 proteins were found in WERI-Rb1. GLUT2 protein was not detected in Y79 or WERI-Rb1. Our findings are of interest because (1) the expression of GLUT protein isoforms in the two retinoblastoma cell lines was different, and (2) GLUT4, protein, the insulin-sensitive GLUT isoform, was detected in Y79. This suggests that these cell lines have different mechanisms of glucose transport. (C) 1997 Japanese Ophthalmological Society.

引用

页码：226 / 230

页数：5

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