Differences in the expression of glucose transporter protein isoforms in human retinoblastoma cell lines

被引：1
|
作者：
Tsukamoto, H [1 ]
Mishima, HK [1 ]
Hirata, K [1 ]
Sato, E [1 ]
Kurokawa, T [1 ]
Ishibashi, S [1 ]
机构：
[1] HIROSHIMA UNIV,SCH MED,DEPT PHYSIOL CHEM,HIROSHIMA 734,JAPAN
来源：
JAPANESE JOURNAL OF OPHTHALMOLOGY | 1997年 / 41卷 / 04期
关键词：
glucose transporter; retinoblastoma; WERI-Rb1; Y79;
D O I：
10.1016/S0021-5155(97)00041-5
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
We investigated the expression of glucose transporter (GLUT) protein isoforms in two human retinoblastoma cell Lines, Y79 and WERI-Rb1, by Western blotting analysis with anti-GLUT1,2,3, and 4 antibodies. GLUT1 and GLUT4 proteins were detected in Y79, whereas GLUT1 and GLUT3 proteins were found in WERI-Rb1. GLUT2 protein was not detected in Y79 or WERI-Rb1. Our findings are of interest because (1) the expression of GLUT protein isoforms in the two retinoblastoma cell lines was different, and (2) GLUT4, protein, the insulin-sensitive GLUT isoform, was detected in Y79. This suggests that these cell lines have different mechanisms of glucose transport. (C) 1997 Japanese Ophthalmological Society.
引用
收藏
页码：226 / 230
页数：5
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