Synthesis, structure, and biological activity of the cis-[4-amino-2,2,6,6-tetramethylpiperidine-N,N′]dichloropalladium(II) complex

被引：1

作者：

Fedorov, B. S. ^{[1
]}

Fadeev, M. A. ^{[1
]}

Kozub, G. I. ^{[1
]}

Golovina, N. I. ^{[1
]}

Utenyshev, A. N. ^{[1
]}

Shilov, G. V. ^{[1
]}

Aldoshin, S. M. ^{[1
]}

Konovalova, N. P. ^{[1
]}

Sashenkova, T. E. ^{[1
]}

Kondrat'eva, T. A. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2013年 / 62卷 / 02期

关键词：

synthesis; complexation with PdCl2; metal complex; cis-[4-amino-2,2,6,6-tetramethylpiperidine-N,N ']dichloropalladium(II); chelate; X-ray diffraction study; antimetastatic activity; toxicity; METAL-COMPLEXES; ANTIMETASTATIC ACTIVITY; PDCL2;

D O I：

10.1007/s11172-013-0080-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A previously unknown palladium complex was synthesized by the reaction of 4-amino-2,2,6,6-tetramethylpiperidine with PdCl2. The X-ray diffraction study showed that the complex formed by 4-amino-2,2,6,6-tetramethylpiperidine with PdCl2 is a chelate, in which the bidentate ligand adopts a boat conformation with the nitrogen atoms occupying cis positions at the palladium atom. The resulting cis-[4-amino-2,2,6,6-tetramethylpiperidine-N,N']dichloro-palladium(ii) complex exhibits strong antimetastatic activity against experimental B16 melanoma at moderate toxicity.

引用

页码：572 / 574

页数：3

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