Synthesis, crystal structure, and biological activity of a nickel(II) complex of 2-acetylpyridine N(4)-methylthiosemicarbazone

被引：11
|
作者：
Chen, Dan-Yun [1 ]
Chen, Chun-Ling [1 ]
Li, Ming-Xue [1 ]
Niu, Jing-Yang [1 ]
Zhu, Xian-Feng [2 ,3 ]
Guo, Hong-Mei [2 ,3 ]
机构：
[1] Henan Univ, Coll Chem & Chem Engn, Inst Mol & Crystal Engn, Kaifeng 475004, Peoples R China
[2] Henan Univ, Bioengn Inst, Kaifeng 475001, Peoples R China
[3] Henan Univ, Coll Life Sci, Kaifeng 475001, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 09期
基金：
中国博士后科学基金;
关键词：
Thiosemicarbazone complex; Crystal structure; Cytotoxic activity; COPPER(II) COMPLEXES; ANTIBACTERIAL ACTIVITY; 2-BENZOYLPYRIDINE-DERIVED THIOSEMICARBAZONES; SPECTRAL CHARACTERIZATION; PALLADIUM(II) COMPLEXES; IRON(III) COMPLEXES; METAL-COMPLEXES; ANTITUMOR; CHEMISTRY;
D O I：
10.1080/00958972.2010.484490
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Nickel complex formulated as Ni(L)2 (L = monodeprotonated ligand corresponding to 2-acetylpyridine N(4)-methylthiosemicarbazone, HL) has been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The complex consists of discrete monomeric molecules with octahedral nickel(II) with two anionic 2-acetylpyridine N(4)-methylthiosemicarbazones as NNS tridentate ligands coordinated to nickel via the pyridine nitrogen, azomethine nitrogen, and sulfur. Hydrogen bonds link the different components to stabilize the crystal structure. Biological studies, carried out in vitro against bacteria, fungi, and the K562 leukemic cell line have shown that the free ligand and complex show distinct differences in biological activity.
引用
收藏
页码：1546 / 1554
页数：9
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