Rho GTPases regulate degranulation and cytokine release from RBL-2H3 cells

被引：0

作者：

Hide, I ^{[1
]}

Itoh, Y ^{[1
]}

Hisahara, T ^{[1
]}

Ido, K ^{[1
]}

Inoue, A ^{[1
]}

Fujiwara, T ^{[1
]}

Aktories, K ^{[1
]}

Sugai, M ^{[1
]}

Nakata, Y ^{[1
]}

机构：

[1] Hiroshima Univ, Inst Pharmaceut Sci, Dept Pharmacol, Hiroshima 7348551, Japan

来源：

HISTAMINE RESEARCH IN THE NEW MILLENNIUM | 2001年 / 1224卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Clostridium difficile Toxin B (toxin B), which inactivates Rho GTPases, Rho, Rac, and Cdc42, inhibited the release of TNF-alpha as well as degranulation from antigen-stimulated RBL-2H3 cells, independently of reorganization of actin microfilaments. Rho-associated kinase (ROCK), one of the downstream effectors of Rho, was selectively involved in the release of TNF-alpha but not in degranulation. Toxin B inhibited the translocation of Ca2+-dependent protein kinase C (alpha and beta isozymes), which plays an important role in the release of TNF-alpha as well as degranulation. These results indicated that Rho GTPases regulate the release of TNF-alpha and degranulation by regulating at least the activation of Ca2+-dependent PKC in antigen-stimulated RBL-2H3 cells.

引用

页码：431 / 432

页数：2

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