Rho GTPases regulate degranulation and cytokine release from RBL-2H3 cells

被引：0

作者：

Hide, I ^{[1
]}

Itoh, Y ^{[1
]}

Hisahara, T ^{[1
]}

Ido, K ^{[1
]}

Inoue, A ^{[1
]}

Fujiwara, T ^{[1
]}

Aktories, K ^{[1
]}

Sugai, M ^{[1
]}

Nakata, Y ^{[1
]}

机构：

[1] Hiroshima Univ, Inst Pharmaceut Sci, Dept Pharmacol, Hiroshima 7348551, Japan

来源：

HISTAMINE RESEARCH IN THE NEW MILLENNIUM | 2001年 / 1224卷

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Clostridium difficile Toxin B (toxin B), which inactivates Rho GTPases, Rho, Rac, and Cdc42, inhibited the release of TNF-alpha as well as degranulation from antigen-stimulated RBL-2H3 cells, independently of reorganization of actin microfilaments. Rho-associated kinase (ROCK), one of the downstream effectors of Rho, was selectively involved in the release of TNF-alpha but not in degranulation. Toxin B inhibited the translocation of Ca2+-dependent protein kinase C (alpha and beta isozymes), which plays an important role in the release of TNF-alpha as well as degranulation. These results indicated that Rho GTPases regulate the release of TNF-alpha and degranulation by regulating at least the activation of Ca2+-dependent PKC in antigen-stimulated RBL-2H3 cells.

引用

页码：431 / 432

页数：2

共 50 条

[21] Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells
Parida Yamada
Takako Ono
Hideyuki Shigemori
Junkyu Han
Hiroko Isoda
Cytotechnology, 2012, 64 : 349 - 356
[22] The inhibitory effect of piperine from Fructus piperis extract on the degranulation of RBL-2H3 cells
Huang, Jing
Zhang, Tao
Han, Shengli
Cao, Jingjing
Chen, Qinhua
Wang, Sicen
FITOTERAPIA, 2014, 99 : 218 - 226
[23] Inhibitors of Antigen-induced Degranulation of RBL-2H3 Cells Isolated from Wheat Bran
Hong, Seong Su
Oh, Joa Sub
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, 2012, 55 (01): : 69 - 74
[24] Inhibition of degranulation of RBL-2H3 cells by casein kinase II substrate peptide
Onose, J
Teshima, R
Nakamura, R
Sawada, J
JOURNAL OF HEALTH SCIENCE, 2003, 49 (03) : 243 - 247
[25] The lectin ArtinM activates RBL-2H3 mast cells without inducing degranulation
Buranello, Patricia A. A.
Barbosa-Lorenzi, Valeria C.
Pinto, Marcelo R.
Pereira-da-Silva, Gabriela
Barreira, Maria Cristina R. A.
Jamur, Maria Celia
Oliver, Constance
PLOS ONE, 2020, 15 (03):
[26] Effects of Flavone Derivatives on Antigen-Stimulated Degranulation in RBL-2H3 Cells
Hwang, Doseok
Park, Hye-Jin
Seo, Eun-Kyung
Oh, Joo Y.
Ji, Sang Y.
Park, Dong K.
Lim, Yoongho
CHEMICAL BIOLOGY & DRUG DESIGN, 2013, 81 (02) : 228 - 237
[27] The functional relation between PKC and actin arrangement in the degranulation from RBL-2H3 cells.
Kuramasu, Maho
Shirai, Yasuhito
Nakamura, Tomofumi
Hide, Izumi
Nakata, Yoshihiro
Saito, Naoaki
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007, 103 : 215P - 215P
[28] A convenient fluorimetry-based degranulation assay using RBL-2H3 cells
Higashio, Hironori
Yokoyama, Takuya
Saino, Tomoyuki
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2024, 88 (02) : 181 - 188
[29] The effect of bile acid analogues on histamine release from RBL-2H3 cells
Yoshii, Michiko
Iwasa, Naomi
Tarao, Ai
Tanaka, Fumi
Ozawa, Koichiro
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, 127 : 117 - 118
[30] Role of PKCalpha-mediated cofilin phosphorylation in the degranulation from RBL-2H3 mast cells
Sakuma, M.
Shirai, Y.
Yoshino, K. -I.
Kuramasu, M.
Nakamura, T.
Yanagita, T.
Mizuno, K.
Hide, I.
Nakata, Y.
Saito, N.
FEBS JOURNAL, 2012, 279 : 175 - 175

← 1 2 3 4 5 →