Understanding the impact of immune-mediated selection on lung cancer evolution

被引：6
|
作者：
Rosenthal, Rachel [1 ,2 ]
Swanton, Charles [1 ,2 ,3 ]
McGranahan, Nicholas [2 ,4 ]
机构：
[1] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England
[2] UCL, Canc Inst, Canc Res UK Lung Canc Ctr Excellence, London, England
[3] Univ Coll London Hosp, Dept Med Oncol, London, England
[4] UCL, Canc Inst, Canc Genome Evolut Res Grp, London, England
来源：
BRITISH JOURNAL OF CANCER | 2021年 / 124卷 / 10期
基金：
欧盟地平线“2020”; 英国惠康基金; 英国医学研究理事会; 欧洲研究理事会;
关键词：
D O I：
10.1038/s41416-020-01232-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.
引用
收藏
页码：1615 / 1617
页数：3
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