Understanding the impact of immune-mediated selection on lung cancer evolution

被引：6

作者：

Rosenthal, Rachel ^{[1
,2
]}

Swanton, Charles ^{[1
,2
,3
]}

McGranahan, Nicholas ^{[2
,4
]}

机构：

[1] Francis Crick Inst, Canc Evolut & Genome Instabil Lab, London, England

[2] UCL, Canc Inst, Canc Res UK Lung Canc Ctr Excellence, London, England

[3] Univ Coll London Hosp, Dept Med Oncol, London, England

[4] UCL, Canc Inst, Canc Genome Evolut Res Grp, London, England

来源：

BRITISH JOURNAL OF CANCER | 2021年 / 124卷 / 10期

基金：

欧盟地平线“2020”; 英国惠康基金; 英国医学研究理事会; 欧洲研究理事会;

关键词：

D O I：

10.1038/s41416-020-01232-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Understanding how a tumour evolves and avoids immune recognition is paramount to improving cancer immunotherapy and patient outcome. Here we examine our recent integration of multi-region genomic, transcriptomic, epigenomic, pathology, and clinical data, highlight the need for a systematic examination of immune escape mechanisms, and discuss implications for immunotherapy approaches.

引用

页码：1615 / 1617

页数：3

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