Cytotoxic T lymphocyte recognition of non-hodgkin's B cell lymphomas

被引：4
|
作者：
Krensky, AM
机构：
[1] Division of Immunology and Transplantation Biology Department of Pediatrics, Stanford University Medical Center, Stanford, A94305-5119, Calif.
来源：
IMMUNOLOGIC RESEARCH | 1996年 / 15卷 / 02期
关键词：
tumor; B cell lymphoma (non-Hodgkin's); Burkitt's lymphoma; cytotoxic T lymphocytes; gamma delta T cell receptor; heat shock proteins; immunotherapy;
D O I：
10.1007/BF02918499
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the gamma,delta T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by gamma,delta T cells.
引用
收藏
页码：91 / 97
页数：7
相关论文
共 50 条
  • [21] Aberrant expression of T-cell antigens on B-cell non-Hodgkin's lymphomas.
    Kaleem, Z
    Kraus, MD
    White, G
    Zutter, MM
    BLOOD, 1997, 90 (10) : 3911 - 3911
  • [22] Stem-cell transplantation in T-cell non-Hodgkin's lymphomas
    Hosing, C.
    Champlin, R. E.
    ANNALS OF ONCOLOGY, 2011, 22 (07) : 1471 - 1477
  • [23] Novel therapies for peripheral T-cell non-Hodgkin's lymphomas
    Cheson, Bruce D.
    CURRENT OPINION IN HEMATOLOGY, 2009, 16 (04) : 299 - 305
  • [24] Microsatellite instability is rare in B-cell non-Hodgkin's lymphomas
    Gamberi, B
    Gaidano, G
    Parsa, N
    Carbone, A
    Roncella, S
    Knowles, DM
    Louie, DC
    Shibata, D
    Chaganti, RSK
    DallaFavera, R
    BLOOD, 1997, 89 (03) : 975 - 979
  • [25] Hepatitis C infection and B-cell non-Hodgkin's lymphomas
    Zuckerman, E
    CLINICAL LYMPHOMA, 2002, 3 (03): : 161 - 162
  • [26] New drugs for B-cell non-Hodgkin's lymphomas (NHL)
    Cheson, B. D.
    ANNALS OF ONCOLOGY, 2008, 19 : 127 - 127
  • [27] Hodgkin's disease and non-Hodgkin lymphomas
    Gutiérrez, EO
    REVISTA CLINICA ESPANOLA, 1999, 199 : 44 - 51
  • [28] Chimeric antigen receptor modified T cell therapy in B cell non-Hodgkin lymphomas
    Levin, Adam
    Shah, Nirav N.
    AMERICAN JOURNAL OF HEMATOLOGY, 2019, 94 : S18 - S23
  • [29] Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin lymphomas and Hodgkin lymphomas
    Ren, Y
    Akyurek, N
    Rassidakis, GZ
    Medeiros, LJ
    LABORATORY INVESTIGATION, 2006, 86 : 243A - 243A
  • [30] Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin lymphomas and Hodgkin lymphomas
    Ren, Y
    Akyurek, N
    Rassidakis, GZ
    Medeiros, LJ
    MODERN PATHOLOGY, 2006, 19 : 243A - 243A
12345