Cytotoxic T lymphocyte recognition of non-hodgkin's B cell lymphomas

被引：4
|
作者：
Krensky, AM
机构：
[1] Division of Immunology and Transplantation Biology Department of Pediatrics, Stanford University Medical Center, Stanford, A94305-5119, Calif.
来源：
IMMUNOLOGIC RESEARCH | 1996年 / 15卷 / 02期
关键词：
tumor; B cell lymphoma (non-Hodgkin's); Burkitt's lymphoma; cytotoxic T lymphocytes; gamma delta T cell receptor; heat shock proteins; immunotherapy;
D O I：
10.1007/BF02918499
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the gamma,delta T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by gamma,delta T cells.
引用
收藏
页码：91 / 97
页数：7
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