Phosphonium ylides stabilized with cyano group and 5-acylamino-4-phenyl-2-thiazolyl residue

被引：0

作者：

Smolii, OB ^{[1
]}

Panchishin, SY ^{[1
]}

Pirozhenko, VV ^{[1
]}

Drach, BS ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan & Petr Chem, Kiev, Ukraine

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2001年 / 71卷 / 11期

关键词：

Hydrogen; Acetic; Chloride; Acetic Acid; Standard Condition;

D O I：

10.1023/A:1013986223340

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Available ylide reagent Ph3P=C(CN)C(S)NH2 readily enters cyclocondensation with N-(chloro-phenacyl)benzamide and its analogs. By this route were prepared new stabilized phosphonium ylides containing cyano group and the corresponding 5-acylamino-4-phenyl-2-thiazolyl fragment. All these compounds even under standard conditions are dephosphorylated under the action of hydrogen chloride in acetic acid to form 5-acylamino-4-phenyl-2-cyanomethylthiazoles in high yields. Their structure was proved by spectroscopic studies and independent synthesis.

引用

页码：1734 / 1736

页数：3

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