Phosphonium ylides stabilized with cyano group and 5-acylamino-4-phenyl-2-thiazolyl residue

Available ylide reagent Ph3P=C(CN)C(S)NH2 readily enters cyclocondensation with N-(chloro-phenacyl)benzamide and its analogs. By this route were prepared new stabilized phosphonium ylides containing cyano group and the corresponding 5-acylamino-4-phenyl-2-thiazolyl fragment. All these compounds even under standard conditions are dephosphorylated under the action of hydrogen chloride in acetic acid to form 5-acylamino-4-phenyl-2-cyanomethylthiazoles in high yields. Their structure was proved by spectroscopic studies and independent synthesis.