The controversial role of Sirtuins in tumorigenesis - SIRT7 joins the debate

被引：13
|
作者：
Li, Ling [1 ]
Bhatia, Ravi [1 ]
机构：
[1] City Hope Natl Med Ctr, Div Hematopoiet Stem Cell & Leukemia Res, Duarte, CA 91010 USA
来源：
CELL RESEARCH | 2013年 / 23卷 / 01期
关键词：
GENE; IDENTIFICATION; PATTERNS; CANCER; CELLS;
D O I：
10.1038/cr.2012.112
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sirtuins are NAD-dependent deacetylases that are conserved from yeast to mammals. A new report sheds light on the function of SIRT7, the least understood member of the Sirtuin family by identifying its locus-pecific H3K18 deacetylase activity, and linking it to maintenance of cellular transformation in malignancies.
引用
收藏
页码：10 / 12
页数：3
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