Transcriptional Regulation of Metabolism by SIRT1 and SIRT7

被引：24
|
作者：
Yamagata, Kazuya [1 ]
Yoshizawa, Tatsuya [1 ]
机构：
[1] Kumamoto Univ, Fac Life Sci, Kumamoto, Japan
来源：
TRANSCRIPTIONAL GENE REGULATION IN HEALTH AND DISEASE | 2018年 / 335卷
关键词：
BROWN ADIPOSE-TISSUE; RNA-POLYMERASE-I; INSULIN SENSITIVITY; RESVERATROL SUPPLEMENTATION; DEPENDENT DEACETYLATION; MITOCHONDRIAL-FUNCTION; CALORIE RESTRICTION; HEPATIC STEATOSIS; ACTIVATING SIRT1; MAMMALIAN SIR2;
D O I：
10.1016/bs.ircmb.2017.07.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sirtuins are a family of evolutionally conserved nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases/deacylases that regulate metabolism. The mammalian sirtuin family consists of seven sirtuins (SIRT1-7). Recent findings have identified critical roles for SIRT1 and SIRT7 in glucose/lipid metabolism in multiple tissues. This review focuses on the metabolic roles of these two sirtuins and the benefits of modulating the activity of sirtuins for the treatment of metabolic diseases such as type 2 diabetes.
引用
收藏
页码：143 / 166
页数：24
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